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Enhanced Tolerance Adding B12 can help reduce common side effects such as nausea, making injections more comfortable and sustainable

(B-D) Traces demonstrate acute effects of Ex-4c on membrane potential when the cell was pretreated with (B) 10 M linopirdine+10 M XE991, (C) 100 nM tertiapin-Q, or (D) 200 M tolbutamide

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The mechanism isnt fully clear but may involve hormonal recalibration

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