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Messer explains, "The major downside to microdosing is the lack of clinical trials to support its use

More than half (55 people) of people with a BMI below 25 report their main motivation for using a weight loss drug is to improve body confidence or self-esteem and around half (52 percent) of this cohort say that celebrity endorsement made them more open to trying the medication." "When prescribed by a registered doctor or a licensed prescribing pharmacist, with appropriate support in place, these medicines can be highly effective for some patients

However, when combined with a sulfonylurea (which forces insulin out regardless of glucose), the combo can cause lows

The court decides which expert testimony is reliable enough to be presented at trial

Hence, validation relies on larger IHC/qPCR-based cohorts and high-resolution single-cell or spatial datasets