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Similarly, in our trial, despite the better glycemic control achieved with oral semaglutide, the proportions of patients with at least one severe or blood glucoseconfirmed symptomatic hypoglycemic episode were similar across treatment arms

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The Lancet Diabetes & Endocrinology 6 , 275286 (2018)

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This distinction matters because it enables effective oral delivery without special formulation, eliminates the need for injections, and could significantly reduce the cost of GLP-1 therapy