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8 9 The Yale study found that retatrutide also raised heart rate

Second, among GLP-1 receptor agonists, only liraglutide and dulaglutide showed increased trends in the risks of overall thyroid disorders compared with placebo and other antidiabetic drugs

Studies have also explored its impact on oxidative stress and inflammation in various biological models

These limitations underscore the need for longer-term, more detailed studies to fully understand semaglutides role in joint health and musculoskeletal outcomes

This is because of the connection between weight and the hypothalamic-pituitary-ovarian axis, according to a 2020 article in The Journal of Clinical Endocrinology and Metabolism