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Furthermore, adverse events are more prominent during dosetitration, 10 typically resolve within a few days, 31 and, in the clinical experience of the second author, are more prominent immediately after administration and improve over time until the next dose

[2] The second part of the ESSENCE trial will extend to 240 weeks, focusing on whether semaglutide lowers the risk of liver-related clinical events compared with placebo.1 Findings are expected to read out in 2029

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One double-blind, placebo-controlled study showed that GLP-1 can decrease aldosterone secretion in healthy individuals suggesting that GLP-1 can act on blood pressure and the reninangiotensinaldosterone system [93]