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Moving from mechanistic observations to clinical implementation will require a structured translational roadmap: Methodological Standardization: Standardizing microbiome sampling, sequencing platforms (transitioning from 16S rRNA to high-resolution shotgun metagenomics), and bioinformatic pipelines to improve reproducibility across international cohorts

In summary, the GM and bone metabolism have a complex and tight association that can affect host metabolism through SCFAs, host immune function through T cells, and host endocrine environment through gut hormones, IGF-1, PTH, and estrogen, thus affecting bone metabolism

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Journal of Research in Medical Sciences, 17 (12), 11611169

Some individuals may prioritize restarting after weaning