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The "Fuss" About GLP-1 Receptor Agonists The excitement surrounding GLP-1 receptor agonists stems from their effectiveness in not just managing blood sugar but also offering additional health benefits like weight loss and cardiovascular protection

In the context of MASLD/MASH, analogous rebound phenomena would be expected: regression of achieved steatosis resolution and potential re-emergence of inflammatory activity and fibrogenic stimuli upon drug withdrawal

The gradual changes are helpful in losing weight

Mechanisms for Surgery-Induced Increases in GLP-1 The mechanisms leading to substantial postprandial release of gut peptides, particularly GLP-1, after bariatric surgery are thought to be largely a consequence of rapid nutrient delivery further down in the GI tract, where the majority of L-cells are located

GLP1R is expressed on beta cells in the pancreas