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The skin of affected patients, especially in those with type 2 diabetes, is more prone to fungal infection and the toe webs are a common port of entry for fungi which can then infect and complicate ulcers (23)

However, it has traditionally been believed that T2D drugs are more efficacious for subjects with higher HbA1C, partly due to the relief of the stress from glucotoxicity [24], and that is what we observed as well
