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Current evidence quality : Most berberine studies are relatively small, short-term (typically 816 weeks), and conducted primarily in Asian populations, which may limit generalisability

Mounjaro, Ozempic and Rybelsus are approved for treating Type 2 diabetes but are commonly prescribed off-label for weight loss

They observed improvements in several pathways, such as liver biochemistry and markers of inflammation, hepatic and systemic insulin sensitivity, insulin sensitivity and lipolysis, hepatic de novo lipogenesis, and hepatic steatosis

Participants were divided into those receiving concurrent hormone therapy and those who were not, with groups carefully matched by age, BMI, and clinical history to reduce the most obvious confounding variables

Gastroenterol Clin North Am