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[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Rugnath R., Orzechowicz C., Newell C., Carullo V., Rugnath A

When a biosimilar is approved based on a clinical program in one indication, the FDA may approve it for all indications held by the reference biologic without separate clinical trials in each, provided the mechanism of action is the same and there is no scientific reason to expect differential clinical behavior across the populations
