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all participants were advised consistently to avoid intense exercise, alcohol and caffeine before their study visit

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Study treatment After a one-week screening period, a region random number table generated by Stata software was used to randomly assign the 78 participants (1:1) to receive 0.2 mg beinaglutide (Shanghai Benemae Pharmaceutical Corporation, Shanghai, China) subcutaneously or 0.5 g metformin orally, three times per day for 12 weeks ( Fig