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A study on mice treated with methionine-choline-deficient diets showed that four-week infusion of liraglutide at a dose of 570 mg/kg/day was associated with the anti-inflammatory effect observed as a reduction in the accumulation of M1 macrophages

This was considered a high-risk proposition because the GLP-1 receptor is a class B G protein-coupled receptor with a large extracellular domain that had been thought to require extensive peptide-receptor contacts for activation

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Other significant safety considerations include a history of pancreatitis, acute kidney injury risk, diabetic retinopathy complications in patients with type 2 diabetes, gallbladder disease, hypoglycemia risk in patients using other diabetes medications, and mental health monitoring for mood changes or suicidal ideation