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Preliminary data point toward beneficial effects of GIP agonism, as reported in findings from the SURPASS program that tirzepatide reduced UACR and slowed down eGFR declined in comparison with both placebo (53) and comparator drugs including insulin glargine (74, 75)

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They start the clinical trial path first with animal trials for several years, then many phases of human trials, et cetera

There is also a known relationship between decreased muscle mass and short term use of glucose

If you have access, its still a good thing to take the medications to lose the weight