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Importantly, efpeglenatides immunogenicity remained relatively low, with few patients developing clinically significant anti-drug antibodies, allowing its safety profile to be viewed as manageable within class expectations

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[DOI] [PubMed] [Google Scholar] 210.Geng S, et al

In the kidney, GLP-1RAs directly induce natriuresis and diuresis by acting on the proximal convoluted tubule (PCT) through inhibition of sodium-hydrogen exchanger 3 (NHE3)

Patients were predominantly female and white
