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Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL

This approach demonstrated long-term therapeutic effect in a dietary-induced obesity mouse model, offering a promising one-shot genome-editing therapy for non-genetic and complex diseases

Data are n (%) in the safety population (modified intentiontotreat population with all the data from the start of treatment to the end of the safety followup in SURPASS2 and data from the ontreatment observation period including events occurring up to 49 d after the last day on trial drug in SUSTAIN FORTE)

Prefer FDA-approved branded products over compounded formulations: Some individuals may prefer FDA-approved branded medications that have undergone extensive clinical trials rather than compounded alternatives
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