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weight loss may reduce limb volume and improve symptoms indirectly

Effect of whey protein supplementation on weight and body composition indicators: A meta-analysis of randomized clinical trials
Neither mechanism directly stimulates insulin secretion in a glucose-independent manner, making the combination inherently safer regarding hypoglycaemia compared to sulphonylureas or insulin

Abbott CR, Rossi M, Wren AM, Murphy KG, Kennedy AR, Stanley SA, et al

It has been demonstrated that GIP concentrations rise during the postprandial period [26, 27], indicating that GIP-producing K cells respond to macronutrient intake [28, 29]
