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By 2000, seven studies had been published on the acute effect of peripheral GLP-1 administration on ad libitum energy intake

3.4 Appetite regulation and weight management Similar to animal studies with deletion of the GIPR gene that exhibit protection toward obesity (53), early genome-wide association studies (GWAS) in humans have revealed the GIPR gene to be associated with BMI (103)

Gastrointestinal tolerance to GLP-1s appears to vary among individuals, with some people experiencing fewer side effects than others

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2-Year Persistence Among GLP-1RA Users Of 1734 individuals who were treated with GLP-1RA, 840 (48.4%) were persistent at 2 years (Table 4)