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A primary outcome event occurred in 12% (579 of 4,825) of patients in the semaglutide group (equivalent to 3.1 events per 100 personyears) and in 13.8% (668 of 4,825) of patients in the placebo group (equivalent to 3.7 events per 100 personyears)

Tzu-chi Medical Journal, 29(3), 143

Gallbladder disease : Rapid weight loss may increase the risk of cholelithiasis (gallstones) and cholecystitis

Overall, 26.7% of patients ( n = 4177) discontinued tirzepatide using the 45-day gap criterion

While these medications offer substantial benefits in terms of weight loss, the rapid shedding of pounds can lead to unintended consequences such as volume loss in specific areas like the face and buttocks