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The drugs connected to these injuries include Ozempic, Wegovy, Rybelsus, and Saxenda (made by Novo Nordisk) and Mounjaro, Zepbound, and Trulicity (made by Eli Lilly)

In addition, phosphorylation of two further serine residues (Ser100 and Ser511) by PKA mediates the recruitment of 14-3-3 adaptor proteins that hold CaMKK2 in an inactivated state by preventing dephosphorylation of phospho-Ser495

however, based on thyroid C-cell hyperplasia, adenomas, and medullary thyroid carcinomas observed in studies of these agents in mice (40), all of the GLP-1 receptor agonists except exenatide BID and lixisenatide are contraindicated in patients with a personal or family history of medullary thyroid carcinoma and in patients with multiple endocrine neoplasia syndrome type 2 (1418)

[DOI] [PMC free article] [PubMed] [Google Scholar] 93.The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial