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It is commonly incorporated into triple-pathway experimental models focused on nutrient sensing, incretin pathway activity, metabolic signaling efficiency, and coordinated energy-balance research under sustained nutrient exposure conditions

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The drugs have become popular for their significant weight-loss effects, but their high cost has made them inaccessible for many patients.

Purpose of Review This review explores the rationale and available evidence behind incretin-based therapies for metabolic dysfunction-associated steatotic disease (MASLD) and metabolic-associated steatohepatitis (MASH), focusing on glucagon-like peptide 1 (GLP-1) and glucagon (GCG) receptor dual agonists (GLP-1/GCG RAs)