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Because of the additional interaction of linagliptin with S2 subsite, it has an eightfold higher activity than alogliptin

Evidence Summary There is limited long-term B12 monitoring data in GLP-1 trials

doi: 10.1056/NEJMoa1607141 12 HernandezAFGreenJBJanmohamedSD'AgostinoRBSrGrangerCBJonesNPet al

The report also identified these lowest-usage states, mostly in coastal and Western regions

Gejl et al
