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To help prescribers, ECRIs Clinical Evidence Assessment service recently published a special report on clinical best practices for managing obesity and overweight with GLP-1 receptor agonists

[22] [23] By activating GLP-1 receptors, these medications enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release, slow gastric emptying, and promote satiety

Additionally, the delayed gastric emptying induced by GLP-1 agonists could theoretically worsen symptoms in patients with stricturing Crohn's disease or those at risk for bowel obstruction

Dermatologic outcomes: GLP-1 RA versus DPP-4i use The mean follow-up duration was 1,080 454 days in the GLP-1 RA group and 1,121 498 days in the DPP-4i group ( Supplementary Figure 1 )

J Neuroinflammation