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"Pulmonary Effects of Herbal Cigarette Smoking." Annals of the American Thoracic Society , 2019 (conference abstract)

Nicotine and other toxic substances in tobacco interfere with oxygen delivery to nerve tissues, leading to chronic pain, weakness, and delayed recovery from neurological conditions

Certain items such as narcotics, hazardous materials are illegal to be sipped in certain regions

doi: 10.1016/0006-8993(94)01386-v

This shift to the products that remain flavored is also evident in sales data, with the market share of disposable e-cigarettes growing from 25.0% in 2020 to 27.5% in 2021, and among disposable e-cigarettes, the market share for flavors other than tobacco, menthol or mint increased from 69.2% in 2020 to 79.4% in 2021