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Taken together, understanding the contributions of immune and metabolic parameters to tumour development is crucial for improving the predictive value and therapeutic strategies for p53 mutant lung cancers
p53 has also been described as a key player in the induction of senescence since, in concert with PI3K/AKT/mTOR signaling, it can drive the cells to an irreversible cell cycle arrest that counteracts oncogenic transformation [82]
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Olivier M, Langerd A, Carrieri P, Bergh J, Klaar S, Eyfjord J, et al
