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As an immunomodulatory compound, CC-220 can lead a substrate specific ubiquitination of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) both essential for antibody production ( Calcineurin inhibitors Activated lupus T cells show an exaggerated calcium response, which leads to early and sustained activation of the phosphatase calcineurin and its substrate, the transcription factor nuclear factor of activated T cells (NFAT)

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Methionine Methionine is an essential sulfur-containing amino acid that is critical for protein synthesis, methylation reactions, and the production of sulfur-containing compounds such as cysteine and glutathione

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