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16 The possibility of these and additional systemic effects warrants large-scale clinical trials to determine a safe and effective dose

Elimination occurs primarily through renal excretion of metabolites, with the peptide and its fragments detectable in urine for up to 4 days following administration despite plasma clearance within hours

Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity

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Modulation of the brain-gut axis and the NO pathway
