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Description
Antioxidants do their work by donating electrons to reactive, oxidized material

This makes red blood cells fragile or scarce
Through stable isotope tracing and chromatin-immunoprecipitation (ChIP) assay, we also found that ACTL6A promotes GSH synthesis by upregulating the rate-limiting enzyme GCLC as a co-transcription factor

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Given that these species can accumulate not only through increased production but also through decreased clearance, an inadequate antioxidant response, particularly associated with a dysregulation of NRF2 transcriptional activity, could explain their gradual accumulation
