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Cambridge, UK: 2015

The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice

Paradoxically, elevated ROS levels and cardiac dysfunction were also observed in DN-NOX4 mice under IR challenge, indicating that high NADPH and GSH levels also enhance ROS generation and induce reductive stress by mechanisms yet to be determined (116)

[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Kang SU, Kim HJ, Kim DH, Han CH, Lee YS, Kim C-H

Although the exact mechanism(s) by which NAC affected the pathways involved in signal transduction and gene expression cannot be delineated from the results of this study, it is possible that these pathways are regulated by oxidants and redox-sensitive steps since increasing levels of intracellular NAC affect the steady state level of oxidants (Figure 3(c)) and can modify the redox status of the cell (Figure 3), an effect known to exert a regulatory effect on transcriptional activation and gene expression [22, 35, 3840]