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[4] The second activation step takes place predominantly in the kidneys where 1-hydroxylase converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D (calcitriol), an active secosteroid hormone that binds nuclear receptors in enterocytes, osteoblasts, renal tubules, parathyroid cells, and numerous immune and endocrine cells to modulate hundreds of genes involved in calcium-phosphate homeostasis, skeletal remodelling, and immunoregulation

Digestive upset: Some patients report nausea, diarrhea, or stomach upset following injections

As a result, GPs and private cosmetic clinics may see more patients presenting with distressing acne like side effects that can be associated with this potential new fad

Methionine and choline two of the four ingredients in our MIC+B12 formula may cause mild nausea, stomach heaviness, or loose stools in sensitive individuals, particularly early in a protocol or on an empty stomach

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