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This is why some patients feel better when T3 is optimized, even if their TSH and T4 are "normal." T3 is less commonly tested because: It's more expensive than TSH or T4 It fluctuates more throughout the day TSH and Free T4 usually provide sufficient information However, Free T3 testing is valuable in certain situations: Suspected hyperthyroidism when TSH is suppressed but T4 is normal Symptoms of hypothyroidism despite "normal" TSH and T4 Monitoring during thyroid hormone replacement therapy Evaluating conversion issues (inability to convert T4 to T3) High Free T3 What it means: Excessive active thyroid hormone, indicating hyperthyroidism

10.2147/NSS.S134864 [DOI] [PMC free article] [PubMed] [Google Scholar] Mezhnina V, Ebeigbe OP, Poe A, Kondratov RV (2022) Circadian control of mitochondria in reactive oxygen species homeostasis