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Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation

INTRODUCTION There is a growing recognition of the importance of glutathione (GSH) physiology, and of the number of physiological functions involving this small but critical tripeptide

10.1046/j.1471-4159.1999.0732447.x 31 BrennanK

This highlights the crucial role of communication between the liver and other organs in the development of PCOS, particularly the essential role of hepatokine-mediated liver-ovarian interaction in PCOS

At low concentrations, ROS facilitate defense against microbes and act as signaling molecules to promote cell proliferation and migration [13]