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Some insurers require documented trial of oral supplementation before approving injections, though this contradicts the pathophysiology-patients with true intrinsic factor deficiency cannot absorb oral B12 regardless of dose
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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Hong Y, Downey T, Eu KW, Koh PK, Cheah PY

A mammalian variant of GST, GSTP, plays a major role in cancer- development and potential drug/chemotherapeutic resistance in a majority of tumor cell lines: The inhibition of the pro-apoptotic pathway (JNK pathway) and the overexpression of GSTP in tumor cells lead to escape of apoptosis of the tumor cells mediated by non GSTP- substance-drugs Hayes et al.,1995 Josephy,2010 Hayes et al.,2000 Fraser et al.,2003
