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One of the proposed mechanisms for the onset of hand-foot syndrome induced by traditional chemotherapy drugs is excretion of the chemotherapy agents via the sweat glands.11 This mechanism could not however be demonstrated for hand-foot skin reaction associated with multikinase inhibitors, as significant levels of sorafenib were not detected in the sweat of these patients.19 In this case, the authors proposed leakage of the drug through capillaries damaged by subclinical trauma as the pathogenic mechanism

In humans, several publications assessed the concentration of valproate in the umbilical cord of neonates at delivery

Wilson-Tang y Cols

Hoogmartens et al., 2021)