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B., Chen, H

Over time, toxins build up in the body, leading to physical and psychological dependence, which necessitates detoxification

Phospholipid hydroperoxide glutathione peroxidase (PHGPx or GPx IV) can reduce lipid peroxides to lipid alcohols (Imai and Nakagawa, 2003)

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For example, GSH forms thioether conjugates with leukotrienes, prostaglandins, hepoxilin, nitric oxide, hydroxyalkenals, ascorbic acid, dopa, dopamine, and maleic acid, and it forms thioesters with cysteine, coenzyme A, proteins, and other cellular thiols (Table 1 and Table 2)