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Lotz-Havla AS, Wei KJ, Schiergens KA, Brunet T, Kohlhase J, Regenauer-Vandewiele S, Maier EM

The discovery of new lipolytic enzymes and coregulators, the demonstration that lipophagy and lysosomal lipolysis contribute to the degradation of cellular lipid stores and the characterization of numerous factors and signalling pathways that regulate lipid hydrolysis on transcriptional and post-transcriptional levels have revolutionized our understanding of lipolysis

B12 deficiency can develop gradually and may present with a range of symptoms, some of which overlap with other conditions

This mechanism enhances fat metabolism and supports body composition improvement without affecting blood glucose, insulin sensitivity, or IGF-1 levels like full-length growth hormone would

This is particularly beneficial for older adults and those at risk of cognitive decline