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Cats are thought to be particularly susceptible to oxidative injury because feline Hb contains 810 reactive sulfhydryl groups rather than 4 as in the dog and other mammalian species (Reference Vajdovich, Gal and Szilgyi16,Reference Kapun, Salobir and Levart41,Reference Gal, Speake and Mezes45,Reference Moyer and Trepanier46)

Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction

GSH stock solutions were freshly prepared by dissolving 1 mg GSH mL 1 in KPE

Good providers adjust formulations based on your health conditions, goals, and previous responses

Fifth, we could not assess medication adherence or concurrent therapies that may have influenced outcomes