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Sulfenic acid formation and overoxidation of essential CYS61

These ADA samples were taken before administration on dosing day for trough levels, For the analysis of serum concentration of GX-G3, blood was collected from tail vein of rats and femoral vein of monkeys on 0, 6, 24, 36, 72, 120 and 168 h after administration on Day 1 and Day 22

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However, aside from this principal role, structural analysis revealed that the fused CPP was shown to interact with CR3 and to contribute to binding free energy