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Several studies have suggested that glutathione levels decline with age and that this decline is associated with an increased risk of age-related decline

79 consecutively demonstrated that Mstn -null mice subjected to ligation of the left anterior descending artery to induce myocardial infarction (MI) exhibited accelerated recovery of the ejection fraction, reduced cardiac fibrosis, and lower mortality, indicating that MSTN negatively affects cardiac function

Sotelo-Orozco J, Chen S-Y, Hertz-Picciotto I, Slupsky CM

In this case, the female curve descends below 0.6 and the male curve descends well below 0.3