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This protective effect is produced by activating the Janus kinase/signal transducer and activator of transcription (JAK2/STAT3) pathway (36)

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Depending on the fundamental biochemical defect, the porphyrias can be broadly classified on the basis of their tissue of origin, the erythropoietic system, or the liver

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Hydrogen Sulfide (H 2 S) Endogenous H 2 S supports basal, physiological, cellular bioenergetic functions, while the activity of this metabolic support decreases with physiological ageing [117]