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In streptozotocin-induced model of AD benfotiamine reduced cognitive deficit, following the increase in ThDP concentrations in hippocampus and entorhinal cortex, brain regions important for memory

10.1039/9781839165153-00263 191 RuddleB

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Interestingly, in cultured glutamatergic cerebellar neurons, it has been shown that the endogenous neurotransmitter glutamate generated from glutamine via PAG can enter the TCA cycle via AAT [55].Our data show an increased production of endogenous [U- 13 C] glutamate synthesised from [U- 13 C] glutamine consistent with an increased PAG expression in the FTD neurons