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Antioxidants 11:606

O-GlcNAc regulates FoxO activation in response to glucose

The critical role of Gpx4 is underscored by the fact that whereas Gpx1-knockout mice are fully viable, Gpx4-knockout animals demonstrate embryonic lethality, and Gpx4 +/ cell lines are markedly sensitive to inducers of oxidative stress, including -irradiation, tert -butyl-hydroperoxide, and hydrogen peroxide, as compared with cell lines derived from wild-type control littermates (147)

Thornton, G

The use of metabolomics offers a fresh approach and viewpoint for understanding the mechanisms of occurrence and development, diagnosis, prognosis, and therapy of viral hepatitis and related diseases
