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Alexander A, et al

Beyond GPX4s protection against lipid peroxide-mediated death in conditions like lupus nephritis, the transcription factor NRF2 bolsters cellular redox defenses, while in heart failure, renal proximal tubules sustain high ATP demand through a finely-regulated iron cycleinvolving transferrin endocytosis, DMT1 transport, mitochondrial use, ferritin storage, and ferroportin exportto conserve iron and prevent its urinary loss (119)

However, that may also limit patient enrollment in clinical trials

Dry, irritated eyes can trigger eyelid spasms

Additionally, there were 151, 20, and 16 OTUs that were exclusive to the control, model, and OMT rats, respectively (Fig