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P827 Pantazidou G
By means of processes like stimulating Treg cell proliferation and encouraging the transformation of M0-type macrophages into M2-type, IDO creates an immunosuppressive milieu in the TME that facilitates tumor evasion of immune surveillance ( IDO1 plays a key role in immune escape in AML, but targeted therapy is still in the early stage of exploration

41 Adverse effects, such as headache, palpitations, nausea and flushing, often occur when used at higher doses

Mesenchymal stem cells alleviate aging in vitro and in vivo

r The development of new primary melanomas is also attributed to this up-regulated pathway and occurs in approximately 1% of patients on BRAF inhibitors
