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Unlike the Phoqus formulation, which appeared to transit the gastrointestinal (GI) tract slower and more predictably than multi-particulates, the rapid transit of the multi-particulates we presumed had resulted in the majority of the drug payload being delivered to the colon, a region of the GI tract wherein the absorption of hydrocortisone had not been formally studied

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Martinez, C

Therefore, claims of its effectiveness for bone, joint, or other healing should be viewed cautiously until more rigorous human trials are conducted

It is also important to note that if an agencys budget exceeds $100 million, they must allocate the maximum amount, 3.2%, to the SBIR program, meaning that some agencies like the DoD and the HHS (NIH) have much larger budgets (and award larger number of companies with higher $) than some of the other agencies with smaller budgets