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The glycolysis modulator TIGAR, a fructose-2,6-bisphosphatase (Fru-2,6-BP), also plays a key role in the modulation of metabolism in response to oxidative stress

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However, factors such as chronic nutrient excess, physical inactivity, genetic predisposition, and aging can drive AT dysfunction, overwhelming its adaptive capacity ( Multiple mechanisms underlie AT dysfunction, including mitochondrial impairment, ER stress, inflammatory pathway activation, and extracellular matrix (ECM) remodeling

Coronary artery calcium scoring does not add prognostic value to standard 64-section CT angiography protocol in low-risk patients suspected of having coronary artery disease