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Description
Article Hall, D.H

As with earlier studies, progressive skin darkening was observed over time, reinforcing MT-2s strong melanogenic activity

Stereological and histological studies exhibited that, after busulfan treatment, some large vacuoles were observed in the semi-niferous tubules in the rat testis and the size of seminiferous tubules was reduced, which was linked to disorganization and reduction of height of germinal epithelium following depletion of spermatogenic lineage cells (spermatogonia, spermatocytes, and round elongated spermatid)

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A point mutation (D697A) was introduced with the Q5 Site-Directed Mutagenesis Kit (E0554S NEB)
