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The upstream regulation of GPX4 mainly include transcription factors such as Nrf2 (Dodson et al., 2019), MYB (Hao et al., 2017), Tfap2c (Alim et al., 2019), Sp1 (Alim et al., 2019), Lipocalin 2 (LCN2) (Chaudhary et al., 2021), mTORC1 (Saxton and Sabatini, 2017

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The group taking MSM reported less muscle soreness and joint pain than the placebo group.(7) These studies indicate that MSM may help reduce pain, muscle damage, and oxidative stress after intense exercise and may aid in quicker recovery

Viral triggers and reactivation As in other chronic diseases, ME/CFS involves an asymptomatic predisposition stage, then a prodromal stage, followed by symptomatic disease (59)