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In summary, the key interactions to consider are pyridoxines reduction of levodopa and anticonvulsant efficacy, niacinamides additive effects on blood pressure, blood sugar, and gout management, and the potential need for B-vitamin repletion in patients on certain medications (diuretics, isoniazid, etc.)

2018 Mar 15;3:CD004655

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If youve previously tried Ozempic or Wegovy and hit a plateau, switching to tirzepatide or adding B12 to your existing semaglutide regimen are both reasonable next steps
