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In this review, we summarized various circadian misalignments, such as altered light-dark, sleep-wake, rest-activity, fasting-feeding, shift work, evening chronotype, and social jetlag, as well as mutations in clock genes that could contribute to the development of diabetes and poor glycemic status in patients with diabetes

Probiotics in the management of inflammatory bowel disease: a systematic review of intervention studies in adult patients
Reck M, von Pawel J, Zatloukal P, et al

Such advancements would augment penetrative efficacy and enhance therapeutic potency, ultimately fostering more effective and sustained clinical outcomes in the management of hyperpigmentation disorders (Figure 3)
