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Abstract Nuclear factor kappa B (NF-B) plays a central role in the inflammatory process, and activation of Keap1-Nrf2 system counteracts with NF-B by upregulating various genes such as superoxide dismutase (SOD), catalase, and heme oxygenase-1 (HO-1)

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Intraperitoneal injection of PMX500FI not only significantly reduced cell apoptosis in the photoreceptor layer of a mouse retinal detachment model and alleviated the inflammatory response accompanied by retinal detachment but also broadly protected the thickness of the outer nuclear layer, thereby maintaining the structural integrity and functional efficacy of the retina [322]

Frye et al
